Acetaminophen/Phenylephrine Drops

Pronunciation: a-SEET-a-MIN-oh-fen/FEN-il-EF-rin
Generic Name: Acetaminophen/Phenylephrine
Brand Name: Tylenol Infants Plus Cold

Acetaminophen/Phenylephrine Drops are used for:

Relieving symptoms such as pain and sinus congestion due to colds, upper respiratory infections, and allergies. It may also used for other conditions as determined by your doctor.

Acetaminophen/Phenylephrine Drops are an analgesic and decongestant combination. The analgesic works in the brain to help decrease pain. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages, which decreases stuffiness.

Do NOT use Acetaminophen/Phenylephrine Drops if:

• you are allergic to any ingredient in Acetaminophen/Phenylephrine Drops


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Phenylephrine Drops:

Some medical conditions may interact with Acetaminophen/Phenylephrine Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, blood vessel problems, stroke, glaucoma, an enlarged prostate or other prostate problems, seizures, an overactive thyroid, severe kidney problems, or liver problems (eg, hepatitis), or if you drink 3 or more drinks with alcohol per day


• if you smoke or have a history of addiction to alcohol

Some MEDICINES MAY INTERACT with Acetaminophen/Phenylephrine Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, hydantoins (eg, phenytoin), indomethacin, isoniazid, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because may increase the risk of Acetaminophen/Phenylephrine Drops's side effects


• Anticoagulants (eg, warfarin), digoxin, or droxidopa because the risk of bleeding, irregular heartbeat, or heart attack may be increased


• Bromocriptine because the risk of its side effects may be increased by Acetaminophen/Phenylephrine Drops


• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Acetaminophen/Phenylephrine Drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Phenylephrine Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Phenylephrine Drops:

Use Acetaminophen/Phenylephrine Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Acetaminophen/Phenylephrine Drops by mouth with or without food.


• Use the dropper that comes with Acetaminophen/Phenylephrine Drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Acetaminophen/Phenylephrine Drops, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Phenylephrine Drops.

Important safety information:

• Acetaminophen/Phenylephrine Drops may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Acetaminophen/Phenylephrine Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not take diet or appetite control medicines while you use Acetaminophen/Phenylephrine Drops unless your doctor tells you to.


• Acetaminophen/Phenylephrine Drops contains acetaminophen and phenylephrine. Before you start any new medicine, check the label to see if it has acetaminophen or a decongestant (eg, phenylephrine) in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better within 7 days or if they get worse, check with your doctor.


• If you have a sore throat that is severe or lasts for more than 2 days, contact your doctor right away. If you have fever, headache, rash, nausea, or vomiting along with or after a sore throat, contact your doctor right away.


• Acetaminophen/Phenylephrine Drops may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Acetaminophen/Phenylephrine Drops. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Acetaminophen/Phenylephrine Drops may harm your liver. Your risk may be greater if you drink alcohol while you are using Acetaminophen/Phenylephrine Drops. Talk to your doctor before you take Acetaminophen/Phenylephrine Drops or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Tell your doctor or dentist that you take Acetaminophen/Phenylephrine Drops before you receive any medical or dental care, emergency care, or surgery.


• Use Acetaminophen/Phenylephrine Drops with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Acetaminophen/Phenylephrine Drops in CHILDREN; they may be more sensitive to its effects.


• Different brands of Acetaminophen/Phenylephrine Drops may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Acetaminophen/Phenylephrine Drops while you are pregnant. Acetaminophen/Phenylephrine Drops are found in breast milk. Do not breast-feed while taking Acetaminophen/Phenylephrine Drops. If you are or will be breast-feeding while you use Acetaminophen/Phenylephrine Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Acetaminophen/Phenylephrine Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; excitability; headache; trouble sleeping; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mood or mental changes; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; tremor; vision changes; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acetaminophen/Phenylephrine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Acetaminophen/Phenylephrine Drops:

Store Acetaminophen/Phenylephrine Drops at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Phenylephrine Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Acetaminophen/Phenylephrine Drops, please talk with your doctor, pharmacist, or other health care provider.


• Acetaminophen/Phenylephrine Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acetaminophen/Phenylephrine Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Acetaminophen/Phenylephrine resources

• Acetaminophen/Phenylephrine Side Effects (in more detail)
• Acetaminophen/Phenylephrine Use in Pregnancy & Breastfeeding
• Acetaminophen/Phenylephrine Drug Interactions
• Acetaminophen/Phenylephrine Support Group
• 1 Review for Acetaminophen/Phenylephrine - Add your own review/rating

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• Headache
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Alcaine

proparacaine hydrochloride

Dosage Form: ophthalmic solution
Alcaine®

(proparacaine hydrochloride

ophthalmic solution, USP) 0.5%

DESCRIPTION:

Alcaine® (proparacaine hydrochloride ophthalmic solution, USP) 0.5% is a topical local anesthetic for ophthalmic use. The active ingredient is represented by the structural formula:

Established name:

Proparacaine Hydrochloride

Chemical name:

Benzoic acid, 3-amino-4-propoxy-,2-(diethylamino) ethyl ester, monohydrochloride.

Molecular Weight: 330.85

Each mL contains: Active: proparacaine hydrochloride 5 mg 0.5%. Preservative: benzalkonium chloride (0.01%). Inactives: glycerin and purified water. The pH may be adjusted with hydrochloric acid and/or sodium hydroxide.

CLINICAL PHARMACOLOGY:

Alcaine® ophthalmic solution is a rapidly-acting topical anesthetic, with induced anesthesia lasting approximately 10-20 minutes.

INDICATIONS AND USAGE:

Alcaine® ophthalmic solution is indicated for procedures in which a topical ophthalmic anesthetic is indicated: corneal anesthesia of short duration, e.g. tonometry, gonioscopy, removal of corneal foreign bodies, and for short corneal and conjunctival procedures.

CONTRAINDICATIONS:

Alcaine® ophthalmic solution should be considered contraindicated in patients with known hypersensitivity to any of the ingredients of this preparation.

WARNINGS:

NOT FOR INJECTION - FOR TOPICAL OPHTHALMIC USE ONLY. Prolonged use of a topical ocular anesthetic is not recommended. It may produce permanent corneal opacification with accompanying visual loss.

PRECAUTIONS:

Carcinogenesis, Mutagenesis, Impairment of Fertility.

Long-term studies in animals have not been performed to evaluate carcinogenic potential, mutagenicity, or possible impairment of fertility in males or females.

Pregnancy: Pregnancy Category C:

Animal reproduction studies have not been conducted with Alcaine® (proparacaine hydrochloride ophthalmic solution, USP) 0.5%. It is also not known whether proparacaine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Proparacaine hydrochloride should be administered to a pregnant woman only if clearly needed.

Nursing Mothers:

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when proparacaine hydrochloride is administered to a nursing woman.

Pediatric Use:

Safety and effectiveness of proparacaine hydrochloride ophthalmic solution in pediatric patients have been established. Use of proparacaine hydrochloride is supported by evidence from adequate and well-controlled studies in adults and children over the age of twelve, and safety information in neonates and other pediatric patients.

Geriatric Use:

No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients.

ADVERSE REACTIONS:

Occasional temporary stinging, burning and conjunctival redness may occur with the use of proparacaine. A rare, severe, immediate-type, apparently hyperallergic corneal reaction characterized by acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and, sometimes, iritis with descemetitis has been reported.

Allergic contact dermatitis from proparacaine with drying and fissuring of the fingertips has also been reported.

DOSAGE AND ADMINISTRATION:

Usual Dosage: Removal of foreign bodies and sutures, and for tonometry: 1 to 2 drops (in single instillations) in each eye before operating.

Short corneal and conjunctival procedures: 1 drop in each eye every 5 to 10 minutes for 5 to 7 doses.

NOTE: Alcaine® (proparacaine hydrochloride ophthalmic solution, USP) 0.5% should be clear to straw-color. If the solution becomes darker, discard the solution.

HOW SUPPLIED:

Alcaine® (proparacaine hydrochloride ophthalmic solution, USP) 0.5% is supplied in 15 mL DROP-TAINER® dispensers.

NDC 0998-0016-15

Storage:

Bottle must be stored in unit carton to protect contents from light. Store bottles under refrigeration at 2° - 8°C (36° - 46°F).

Rx Only

©2004 Alcon, Inc.

ALCON LABORATORIES, INC.

6201 South Freeway

Fort Worth, Texas 76134 USA

Printed in USA

MedInfo@AlconLabs.com

1-800-757-9195

249039-0609

PRINCIPAL DISPLAY PANEL

NDC 0998-0016-15

Alcon®

Alcaine®

(proparacaine hydrochloride ophthalmic solution USP) 0.5%

15 mL Sterile

  

Alcaine  proparacaine hydrochloride  solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0998-0016 Route of Administration OPHTHALMIC DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PROPARACAINE HYDROCHLORIDE (PROPARACAINE) PROPARACAINE HYDROCHLORIDE 5 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength BENZALKONIUM CHLORIDE   GLYCERIN   WATER   HYDROCHLORIC ACID   SODIUM HYDROXIDE

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0998-0016-15 15 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA080027	10/19/1973

Labeler - Alcon Laboratories, Inc. (008018525)

Registrant - Alcon Laboratories, Inc. (008018525)

Establishment
Name	Address	ID/FEI	Operations
Alcon Laboratories, Inc.		008018525	MANUFACTURE

Revised: 08/2011Alcon Laboratories, Inc.

More Alcaine resources

• Alcaine Side Effects (in more detail)
• Alcaine Dosage
• Alcaine Use in Pregnancy & Breastfeeding
• Alcaine Support Group
• 0 Reviews · Be the first to review/rate this drug

• Alcaine Advanced Consumer (Micromedex) - Includes Dosage Information


• Alcaine Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Adalat CC

Generic Name: nifedipine (Oral route)

nye-FED-i-peen

Commonly used brand name(s)

In the U.S.

• Adalat CC


• Afeditab CR


• Nifediac CC


• Nifedical XL


• Procardia


• Procardia XL

Available Dosage Forms:

• Capsule, Liquid Filled


• Tablet, Extended Release


• Tablet


• Capsule

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Dihydropyridine

Uses For Adalat CC

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Before Using Adalat CC

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Carbamazepine


• Phenobarbital


• Phenytoin


• Rifabutin


• Rifampin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Atazanavir


• Clarithromycin


• Dantrolene


• Fentanyl


• Mibefradil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Atenolol


• Betaxolol


• Bevantolol


• Bisoprolol


• Bucindolol


• Carteolol


• Carvedilol


• Celiprolol


• Cimetidine


• Clopidogrel


• Dalfopristin


• Dilevalol


• Diltiazem


• Doxazosin


• Esmolol


• Fluconazole


• Ginkgo


• Ginseng


• Indinavir


• Itraconazole


• Ketoconazole


• Labetalol


• Levobunolol


• Magnesium


• Mepindolol


• Metipranolol


• Metoprolol


• Micafungin


• Nadolol


• Nafcillin


• Nebivolol


• Oxprenolol


• Penbutolol


• Pindolol


• Propranolol


• Quinidine


• Quinupristin


• Rifapentine


• Sotalol


• St John's Wort


• Tacrolimus


• Talinolol


• Tertatolol


• Timolol


• Vincristine


• Vincristine Liposome

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Aortic stenosis (narrowing of a valve in your heart) or


• Bowel blockage, severe or


• Congestive heart failure or


• Coronary artery disease or


• Heart attack or


• Hypotension (low blood pressure)—Use with caution. May increase risk of serious side effects.

• Cardiogenic shock (shock caused by heart attack)—Should not be used in patients with these conditions.

• Galactose intolerance (rare hereditary problem) or


• Glucose-galactose malabsorption (rare hereditary problem) or


• Lapp lactase deficiency (rare hereditary problem)—The extended release tablet form of this medicine contains lactose (milk sugar), and should not be given to patients with these conditions.

• Kidney problems or


• Liver problems (including cirrhosis)—Use with caution. The effects of nifedipine may be increased because of the slower removal of the medicine from the body.

Proper Use of nifedipine

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalat CC. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For treatment of chest pain or high blood pressure:
  
  • For oral dosage form (capsules):
    
    • Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Adalat CC

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

You should not use this medicine if you are also taking certain other medications such as carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), or St. John's Wort. Using these medicines together can cause serious problems. Make sure your doctor knows all of the medications you are taking.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. These symptoms are more likely to occur when you begin taking this medicine, or when the dose is increased.

This medicine may cause fluid retention (edema) in some patients. Tell your doctor right away if you have bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or loss.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. This medicine may affect the results of certain medical tests.

Grapefruits and grapefruit juice may increase the effects of nifedipine by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you taking this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Adalat CC Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bloating or swelling of the face, arms, hands, lower legs, or feet


• cough


• difficult or labored breathing


• dizziness or lightheadedness


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling of warmth


• headache


• muscle cramps


• rapid weight gain


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• tightness in the chest


• tingling of the hands or feet


• trembling or shaking of the hands or feet


• unusual weight gain or loss


• weakness


• wheezing

Less common

• Blue lips and fingernails


• chest congestion


• chest pain


• chills


• coughing that sometimes produces a pink frothy sputum


• decreased urine output


• difficult, fast, or noisy breathing, sometimes with wheezing


• dilated neck veins


• extreme fatigue


• fever


• increased sweating


• irregular breathing


• nausea


• pain or discomfort in the arms, jaw, back, or neck


• pale skin


• severe unusual tiredness or weakness


• sweating


• troubled breathing


• vomiting

Rare

• Black, tarry stools


• bleeding gums


• blood in the eyes


• blood in the urine or stools


• bloody stools


• bluish color


• blurred vision


• body aches or pain


• changes in skin color


• cold sweats


• dark urine


• difficulty with swallowing


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• dry mouth


• dryness or soreness of throat


• ear congestion or pain


• extra heartbeats


• eye pain


• feeling unusually cold


• general tiredness and weakness


• headache, severe and throbbing


• hoarseness


• increased urge to urinate during the night


• irritation in the mouth


• itching


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• light-colored stools


• nasal congestion


• neck pain


• nervousness


• no blood pressure or pulse


• noisy breathing


• pain


• pain in the groin or genitals


• pain or burning while urinating


• painful or difficult urination


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness and swelling of the gums


• redness in the whites of the eyes


• runny nose


• shakiness and unsteady walk


• sharp back pain just below ribs


• shivering


• skin rash


• small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope


• sneezing


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• stopping of heart


• swelling around the eyes


• swollen glands


• tenderness


• tender, swollen glands in the neck


• troubled breathing with exertion


• unconsciousness


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual bleeding or bruising


• upper right abdominal or stomach pain


• vision changes


• voice changes


• vomiting of blood or material that looks like coffee grounds


• waking to urinate at night


• yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Belching


• feeling of indigestion


• mood changes


• pain in the chest below the breastbone


• redness of the face, neck, arms, and occasionally, upper chest

Less common

• Abnormal ejaculation


• bloody nose


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• decreased interest in sexual intercourse


• decreased sexual performance or desire


• diarrhea


• difficulty having a bowel movement (stool)


• excess air or gas in stomach or intestines


• feeling of constant movement of self or surroundings


• full feeling


• general feeling of discomfort or illness


• inability to have or keep an erection


• increased need to urinate


• joint stiffness


• leg cramps or pain


• loss in sexual ability, desire, drive, or performance


• nervousness


• passing gas


• passing urine more often


• sneezing


• stuffy nose


• trouble sleeping

Rare

• Acid or sour stomach


• ankle, knee, or great toe joint pain


• cracks in the skin


• difficulty with moving


• discouragement


• excessive muscle tone


• fear or nervousness


• feeling sad or empty


• hair loss or thinning of the hair


• heartburn


• increased sensitivity of the skin to sunlight


• irritability


• itching, pain, redness, swelling, tenderness, or warmth on the skin


• lack of appetite


• lack or loss of strength


• loss of heat from the body


• loss of interest or pleasure


• loss of strength or energy


• loss in sexual ability, desire, drive, or performance


• lower back or side pain


• muscle pain or weakness


• muscle stiffness


• muscle tension or tightness


• pain or burning in the throat


• red, swollen skin


• redness or other discoloration of the skin


• scaly skin


• severe sunburn


• sleepiness or unusual drowsiness


• sleeplessness


• stomach discomfort, upset, or pain


• swelling of the breasts or breast soreness in both females and males


• tiredness


• trouble concentrating


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Adalat CC side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Adalat CC resources

• Adalat CC Side Effects (in more detail)
• Adalat CC Use in Pregnancy & Breastfeeding
• Drug Images
• Adalat CC Drug Interactions
• Adalat CC Support Group
• 1 Review for Adalat CC - Add your own review/rating

• Adalat CC Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Adalat CC Prescribing Information (FDA)


• Adalat Consumer Overview


• Afeditab CR Prescribing Information (FDA)


• Nifediac CC Prescribing Information (FDA)


• Nifedical XL Prescribing Information (FDA)


• Nifedipine Monograph (AHFS DI)


• Nifedipine Professional Patient Advice (Wolters Kluwer)


• Nifedipine MedFacts Consumer Leaflet (Wolters Kluwer)


• Procardia Prescribing Information (FDA)


• Procardia XL Prescribing Information (FDA)

Compare Adalat CC with other medications

• High Blood Pressure

Aquamephyton

Generic Name: phytonadione (fye toe na DYE own)

Brand Names: Mephyton, Vitamin K1

What is Aquamephyton (phytonadione)?

Phytonadione is a man-made form of vitamin K. Phytonadione is important in the production of substances that cause the blood to clot.

Phytonadione is used to treat vitamin K deficiency and to treat certain bleeding or blood clotting problems.

Phytonadione may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Aquamephyton (phytonadione)?

Tell your doctor and dentist that you are taking phytonadione before having any type of surgery.

What should I discuss with my healthcare provider before taking Aquamephyton (phytonadione)?

Phytonadione may affect other medical conditions or treatments. Talk to your doctor before taking phytonadione if you have other health problems or conditions, or if you take other medications.

Phytonadione is in the FDA pregnancy category C. This means that it is not known whether phytonadione will be harmful to an unborn baby. Do not take phytonadione without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether phytonadione passes into breast milk and if it will affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Aquamephyton (phytonadione)?

Take phytonadione exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each oral dose with a full glass of water.

Injectable forms of phytonadione are usually administered by a healthcare professional. If you are injecting phytonadione at home, your doctor or nurse will give you detailed instructions regarding preparation, administration, and storage of the medication.

Do not take more phytonadione than is prescribed.

It is important to take phytonadione regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with phytonadione to monitor progress and side effects.

Store phytonadione at room temperature away from moisture and heat. Protect phytonadione from light, as light decreases the effectiveness of the medication.

What happens if I miss a dose?

Contact your doctor if you miss a dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a phytonadione overdose are not known.

What should I avoid while taking Aquamephyton (phytonadione)?

Tell your doctor and dentist that you are taking phytonadione before having any type of surgery.

Aquamephyton (phytonadione) side effects

Seek emergency medical attention or contact your doctor immediately if you experience any serious side effects from phytonadione such as:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  
  


• 
  

  dizziness;

  
  


• 
  

  fast or irregular heartbeats; or

  
  


• 
  

  increased sweating.

  
  

Other less serious side effects may be more likely to occur. Continue to use phytonadione and talk to your doctor if you experience

• 
  

  flushing of the face;

  
  


• 
  

  an unusual taste in the mouth; or

  
  


• 
  

  pain or irritation at the injection site (injectable form).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Aquamephyton (phytonadione)?

Before taking phytonadione, tell your doctor about all other medicines you are taking, especially any of the following:

• 
  

  warfarin (Coumadin);

  
  


• 
  

  mineral oil;

  
  


• 
  

  orlistat (Xenical);

  
  


• 
  

  cholestyramine (Questran, Prevalite);

  
  


• 
  

  a salicylate such as aspirin (Acuprin, Ecotrin, Ascriptin, Bayer, others); choline salicylate and/or magnesium salicylate (Magan, Doan's, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal), or salsalate (Disalcid);

  
  


• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Voltaren, Cataflam), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), or tolmetin (Tolectin); or


• 
  

  an antibiotic.

  
  

You may not be able to take phytonadione, or you may require a dosage adjustment or special monitoring during treatment.

Medications other than those listed here may also interact with phytonadione. Tell your doctor about all other prescription and over-the-counter medicines that you take, including vitamins, minerals, and herbal products.

More Aquamephyton resources

• Aquamephyton Side Effects (in more detail)
• Aquamephyton Use in Pregnancy & Breastfeeding
• Aquamephyton Drug Interactions
• Aquamephyton Support Group
• 0 Reviews for Aquamephyton - Add your own review/rating

• Phytonadione Prescribing Information (FDA)


• Phytonadione Monograph (AHFS DI)


• Phytonadione MedFacts Consumer Leaflet (Wolters Kluwer)


• Mephyton Advanced Consumer (Micromedex) - Includes Dosage Information


• Mephyton Prescribing Information (FDA)


• Mephyton MedFacts Consumer Leaflet (Wolters Kluwer)


• Vitamin K1 Prescribing Information (FDA)

Compare Aquamephyton with other medications

• Hypoprothrombinemia, Anticoagulant Induced
• Hypoprothrombinemia, Not Associated with Anticoagulant Therapy
• Hypoprothrombinemia, Prophylaxis
• Vitamin K Deficiency

Where can I get more information?

• Your pharmacist has more information about phytonadione written for health professionals that you may read.

See also: Aquamephyton side effects (in more detail)

Azacitidine

Pronunciation: AY-za-SYE-ti-deen
Generic Name: Azacitidine
Brand Name: Vidaza

Azacitidine is used for:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.

Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.

Do NOT use Azacitidine if:

• you are allergic to any ingredient in Azacitidine or to mannitol


• you have advanced liver cancer

Contact your doctor or health care provider right away if any of these apply to you.

Before using Azacitidine:

Some medical conditions may interact with Azacitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are able to become pregnant


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney or liver problems

Some MEDICINES MAY INTERACT with Azacitidine. However, no specific interactions with Azacitidine are known at this time.

Ask your health care provider if Azacitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Azacitidine:

Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Azacitidine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Azacitidine at home, a health care provider will teach you how to use it. Be sure you understand how to use Azacitidine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Azacitidine if it contains particles, is discolored, or if the vial is cracked or damaged.


• You may receive certain other medicines before Azacitidine to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.


• If Azacitidine comes into contact with the skin, immediately and thoroughly wash it off with soap and water. If it comes into contact with mucous membranes (eg, eyes, nose, mouth, vagina), flush thoroughly with water.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Azacitidine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Azacitidine.

Important safety information:

• Azacitidine may cause dizziness, fainting, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Azacitidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Azacitidine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Tell your doctor or dentist that you take Azacitidine before you receive any medical or dental care, emergency care, or surgery.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Azacitidine may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Azacitidine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Men should not father a child while using Azacitidine. Talk with your doctor about using effective methods of birth control while using Azacitidine.


• Lab tests, including liver function tests, kidney function tests, and blood cell counts, may be performed while you use Azacitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Azacitidine with caution in the ELDERLY; they may be more sensitive to its effects.


• Azacitidine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Azacitidine may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Azacitidine while you are pregnant. It is not known if Azacitidine is found in breast milk. Do not breast-feed while taking Azacitidine.

Possible side effects of Azacitidine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding at the injection site; blood in the urine; chest pain; confusion; dark urine; decreased or painful urination; fainting; fever, chills, or persistent sore throat; irregular heartbeat; mouth or tongue swelling or soreness; muscle pain, weakness, or cramping; numbness of an arm or leg; one-sided weakness; seizures; severe or persistent dizziness or headache; shortness of breath; slurred speech; stomach or leg pain; swelling of the hands, arms, ankles, feet, or legs; unusual bruising or bleeding; unusual or severe tiredness or weakness; vision changes; weight loss; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Azacitidine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; nausea; vomiting.

Proper storage of Azacitidine:

Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.

General information:

• If you have any questions about Azacitidine, please talk with your doctor, pharmacist, or other health care provider.


• Azacitidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Azacitidine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Azacitidine resources

• Azacitidine Side Effects (in more detail)
• Azacitidine Use in Pregnancy & Breastfeeding
• Azacitidine Drug Interactions
• Azacitidine Support Group
• 3 Reviews for Azacitidine - Add your own review/rating

• Azacitidine Professional Patient Advice (Wolters Kluwer)


• Azacitidine Monograph (AHFS DI)


• Vidaza Consumer Overview


• Vidaza Prescribing Information (FDA)


• azacitidine Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Azacitidine with other medications

• Myelodysplastic Syndrome

atorvastatin

a-tor-va-STAT-in

Commonly used brand name(s)

In the U.S.

• Lipitor

Available Dosage Forms:

• Tablet

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: HMG-COA Reductase Inhibitor

Uses For atorvastatin

Atorvastatin is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. Using atorvastatin may help prevent medical problems (e.g., chest pain, heart attack, or stroke) caused by such substances clogging the blood vessels. atorvastatin may also be used to prevent certain types of heart problems in adults with risk factors for heart problems .

Atorvastatin belongs to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. It works by blocking an enzyme that is needed by the body to make cholesterol, thereby reducing the amount of cholesterol in the blood.

Atorvastatin is available only with your doctor's prescription.

Importance of Diet

Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.

Also, atorvastatin is less effective if you are greatly overweight. It may be very important for you to go on a weight-reducing diet. However, check with your doctor before going on any diet.

Before Using atorvastatin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For atorvastatin, the following should be considered:

In addition to its helpful effects in treating your medical problem, this type of medicine may have some harmful effects.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to atorvastatin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

atorvastatin is safe to use in boys and some girls 10 to 17 years of age for treating certain types of high cholesterol.

Geriatric

atorvastatin has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different problems in older people than it does in younger adults. However, blood levels of atorvastatin tend to be higher in older people than they do in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking atorvastatin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using atorvastatin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Telaprevir

Using atorvastatin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atazanavir


• Bezafibrate


• Ciprofibrate


• Clarithromycin


• Clofibrate


• Conivaptan


• Dalfopristin


• Danazol


• Daptomycin


• Diltiazem


• Erythromycin


• Fenofibrate


• Fluconazole


• Fusidic Acid


• Gemfibrozil


• Itraconazole


• Ketoconazole


• Mibefradil


• Nefazodone


• Niacin


• Posaconazole


• Quinupristin


• Telithromycin


• Tipranavir


• Troleandomycin


• Verapamil

Using atorvastatin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amprenavir


• Azithromycin


• Bexarotene


• Black Cohosh


• Bosentan


• Colchicine


• Cyclosporine


• Darunavir


• Digoxin


• Efavirenz


• Eltrombopag


• Etravirine


• Fosamprenavir


• Fosphenytoin


• Indinavir


• Lopinavir


• Nelfinavir


• Oat Bran


• Pectin


• Phenytoin


• Pioglitazone


• Quinine


• Rifampin


• Saquinavir


• St John's Wort


• Voriconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using atorvastatin with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use atorvastatin, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of atorvastatin. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Liver disease, history—Use with caution. These conditions may increase the amount of atorvastatin in your blood .

• Convulsions (seizures), not well-controlled, or


• Electrolyte or metabolic enzyme deficiencies or disorders or


• Infection, severe or


• Low blood pressure or


• Major surgery or trauma, recent—Patients with these conditions may be at risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure.

• Kidney disease, severe—Use with caution. atorvastatin may make the condition worse .

• Liver disease, active or


• Liver enzymes, persistently high levels—atorvastatin should not be used in these conditions. Use of atorvastatin may make liver problems worse .

• Stroke, recent or


• Transient ischemic attack (TIA), recent—Atorvastatin may increase the risk of stroke in patients with any of these conditions .

Proper Use of atorvastatin

Use atorvastatin only as directed by your doctor. Do not use more or less of it, and do not use it more often or for a longer time than your doctor ordered. Also, atorvastatin works best if there is a constant amount in the blood. To help keep this amount constant, do not miss any doses and take the medicine at the same time each day.

Remember that atorvastatin will not cure your condition but it does help control it. Therefore, you must continue to take it as directed if you expect to keep your cholesterol levels down.

Follow carefully the special diet your doctor gave you. This is the most important part of controlling your condition and is necessary if the medicine is to work properly.

Atorvastatin should not be taken with large amounts of grapefruit juice or other grapefruit products because these may increase the concentrations of atorvastatin in the body.

atorvastatin may be taken with or without food .

Dosing

The dose of atorvastatin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of atorvastatin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For high cholesterol:
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 10 or 20 milligrams (mg) once daily. Your doctor may increase your dose up to a maximum of 80 mg per day if needed.
    
    
    • Children (10 to 17 years of age)—At first, 10 milligrams (mg) once daily. Your doctor may increase your dose up to a maximum of 20 mg per day if needed.
    
    
    • Children (less than 10 years of age)—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of atorvastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using atorvastatin

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride levels and to decide if you should continue to take it.

Check with your doctor immediately if you think that you may be pregnant. HMG-CoA reductase inhibitors may cause birth defects or other problems in the baby if taken during pregnancy.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking atorvastatin.

Do not take over-the-counter (OTC) niacin preparations without consulting your doctor. Niacin may increase atorvastatin's adverse effects on muscle, which can lead to serious kidney problems.

Do not use excessive amounts of alcohol while taking atorvastatin because it can worsen the adverse effects of atorvastatin on the liver.

Check with your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by unusual tiredness or fever, because the medicine's adverse effects on muscle can lead to serious kidney problems.

atorvastatin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

• Cough


• difficulty swallowing


• dizziness


• fast heartbeat


• hives


• itching


• muscle cramps, pain, stiffness, swelling, or weakness, especially if accompanied by unusual tiredness or fever


• persistent elevation of liver function tests


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• shortness of breath


• skin rash


• tightness in chest


• unusual tiredness or weakness


• wheezing

Frequency not determined

• Blistering, peeling, loosening of skin


• chills


• dark-colored urine


• diarrhea


• fever


• itching


• joint pain


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• red skin lesions, often with a purple center sore


• red, irritated eyes


• redness, tenderness, itching, burning, or peeling of skin


• sore throat


• sores, ulcers, or white spots in mouth or on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache


• hoarseness


• lower back or side pain


• pain or tenderness around eyes and cheekbones


• painful or difficult urination


• stuffy or runny nose

Less common

• Abdominal pain


• accidental injury


• back pain


• belching or excessive gas


• constipation


• general feeling of discomfort or illness


• heartburn, indigestion, or stomach discomfort


• lack or loss of strength


• loss of appetite


• nausea


• shivering


• sweating


• trouble sleeping


• vomiting

Frequency not determined

• Appetite increased


• black, tarry stools


• blindness


• bloody nose


• bloody or cloudy urine


• bluish color changes in skin


• blurred vision


• bruising, large, flat, blue patches on the skin


• chapped, red, or swollen lips


• continuing ringing or buzzing or other unexplained noise in ears


• depersonalization


• difficult, burning, or painful urination


• difficulty seeing at night


• dysphoria


• euphoria


• excessive muscle tone or tension


• frequent urge to urinate or defecate


• fruit-like breath odor


• groin or scrotum pain


• inability to have or keep an erection


• increased body movements


• increased sensitivity of eyes to light


• increased sensitivity to touch or pain


• increased thirst


• increased urination


• loss of bladder control


• loss of sexual ability, drive, or desire


• lumps in breasts


• mental depression


• nervousness


• nightmares


• normal menstrual bleeding occurring earlier or lasting longer


• pale skin


• paranoia


• pinpoint red spots on skin


• slurred speech


• swollen or tender lymph glands in neck, armpit, or groin


• transient, mild, pleasant aromatic odor


• unable to move or feel face


• unusual bleeding or bruising


• weight loss


• yellow skin or eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: atorvastatin side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More atorvastatin resources

• Atorvastatin Side Effects (in more detail)
• Atorvastatin Dosage
• Atorvastatin Use in Pregnancy & Breastfeeding
• Atorvastatin Drug Interactions
• Atorvastatin Support Group
• 26 Reviews for Atorvastatin - Add your own review/rating

• Atorvastatin MedFacts Consumer Leaflet (Wolters Kluwer)


• Atorvastatin Prescribing Information (FDA)


• Atorvastatin Calcium Monograph (AHFS DI)


• Lipitor Prescribing Information (FDA)


• Lipitor Consumer Overview

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• Prevention of Cardiovascular Disease
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Adrenal Super Boost

Generic Name: onosmodium, acidum phosphoricum, gelsemium granule

Dosage Form: FOR ANIMAL USE ONLY
Adrenal Super Boost

Relieves adrenal fatigue

Indications: Homeopathic remedy for the relief of adrenal fatigue in pets.

Dosage: Sprinkle granules directly into the mouth and hold closed briefly.  Initial dose: Every 30 minutes for up to 10 doses. Thereafter, 3 times daily.  Cats and dogs under 20 lbs:1 large pinch. Dogs 20-50 lbs: 2 pinches.  Dogs over 50 lbs: ¼ cap granules.  May be used with Energy Tonic™.

Caution: Consult your vet if symptoms persist or worsen. Keep this and all medicines from the reach of children.

Ingredients: Each dose contains equal parts of Onosmodium (6C) (HPUS), Acidum phosphoricum (6C) (HPUS), Gelsemium (6C) (HPUS)

Sucrose (inactive ingredient).

Contains no gluten, artificial flavors, colors or preservatives.

All Native Remedies health products are especially formulated by experts in the field of natural health and are manufactured according to the highest pharmaceutical standards for maximum safety and effectiveness. For more information, visit us at www.petalive.com

Distributed by

Native Remedies, LLC

6531 Park of Commerce Blvd.  Suite 160

Boca Raton, FL 33487

Phone: +1.877.289.1235

International: +1.561.999.8857

The letters HPUS indicate that the component(s) in this product is (are) officially monographed in the Homeopathic Pharmacopoeia of the United States.

Keep this and all medicines from the reach of children.

Adrenal Super Boost  onosmodium, acidum phosphoricum, gelsemium   granule

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 68647-186 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ONOSMODIUM VIRGINIANUM (ONOSMODIUM VIRGINIANUM) ONOSMODIUM VIRGINIANUM 6 [hp_C]  in 40 mg PHOSPHORIC ACID (PHOSPHORIC ACID) PHOSPHORIC ACID 6 [hp_C]  in 40 mg GELSEMIUM SEMPERVIRENS ROOT (GELSEMIUM SEMPERVIRENS ROOT) GELSEMIUM SEMPERVIRENS ROOT 6 [hp_C]  in 40 mg

Inactive Ingredients Ingredient Name Strength SUCROSE 20000 mg  in 20000 mg

Product Characteristics Color white (white sucrose granules) Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 68647-186-10 20000 mg In 1 BOTTLE, GLASS None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved homeopathic		01/01/2010

Labeler - Feelgood Health (538418296)

Establishment
Name	Address	ID/FEI	Operations
W.Last		567284153	manufacture

Revised: 09/2010Feelgood Health

Atarax

Pronunciation: hye-DROX-i-zeen
Generic Name: Hydroxyzine
Brand Name: Examples include Atarax and Vistaril

Atarax is used for:

Treating anxiety, for sedation before and after general anesthesia, and to treat itching due to certain allergic conditions, including hives and contact dermatitis (eg, poison ivy). It also may be used for other conditions as determined by your doctor.

Atarax is an antihistamine. It works by affecting the brain to reduce anxiety. It also has other activities, including opening breathing tubes, relieving pain or allergy symptoms, and preventing or treating nausea and vomiting caused by motion sickness.

Do NOT use Atarax if:

• you are allergic to any ingredient in Atarax


• you are taking sodium oxybate (GHB)


• you are in your first 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Atarax:

Some medical conditions may interact with Atarax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have asthma, glaucoma, difficulty urinating, urinary or intestinal blockage, a prostate disease, or a blood disease


• if you drink alcoholic beverages

Some MEDICINES MAY INTERACT with Atarax. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because side effects such as an increase in sleep duration and slowed breathing may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Atarax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Atarax:

Use Atarax as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Atarax by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you miss a dose of Atarax and you are using it regularly, take it as soon as possible. If it is almost time for you next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Atarax.

Important safety information:

• Atarax may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Atarax with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Avoid drinking alcohol or using medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Atarax; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• The effectiveness of Atarax as anxiety treatment for longer than 4 months is not known.


• Use Atarax with caution in the ELDERLY; they may be more sensitive to its effects.


• Atarax should not be used in NEWBORNS; safety and effectiveness in newborns have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Atarax if you are in your first 3 months of pregnancy. If you think you may be pregnant, contact your doctor right away. It is not known if Atarax is found in breast milk. Do not breast-feed while taking Atarax.

Possible side effects of Atarax:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); involuntary movements.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Atarax side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include unusual drowsiness and dizziness.

Proper storage of Atarax:

Store Atarax at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light in a tightly closed container. Do not store in the bathroom. Keep Atarax out of the reach of children and away from pets.

General information:

• If you have any questions about Atarax, please talk with your doctor, pharmacist, or other health care provider.


• Atarax is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Atarax. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Atarax resources

• Atarax Side Effects (in more detail)
• Atarax Use in Pregnancy & Breastfeeding
• Drug Images
• Atarax Drug Interactions
• Atarax Support Group
• 27 Reviews for Atarax - Add your own review/rating

• Atarax Consumer Overview


• Atarax Prescribing Information (FDA)


• Hydroxyzine Prescribing Information (FDA)


• Hydroxyzine Professional Patient Advice (Wolters Kluwer)


• Hydroxyzine Hydrochloride Monograph (AHFS DI)


• Vistaril Prescribing Information (FDA)


• Vistaril Consumer Overview

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